Platelet metabolic remodeling in thrombosis

¹ Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, Fujian Province, China

² The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Health Science Center, Beijing 100191, China

*Corresponding Author:

Yansong Guo, Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 134 East Street, Fuzhou 350001,

Fujian Province, China. Email: ysguo1234@163.com; https://orcid.org/0000-0002-7099-793X

MTM 2025 , 3(2), 1–5; https://doi.org/10.54844/mtm.2023.0422

© 2025 by the Min Fei, Yansong Guo,Huiqing Wang, Nan Lin. Licensee Porcelain Publishing, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )

Abstract

Many human diseases are associated with hyperactivity of platelet metabolism. Understanding in detail the connection between metabolic changes and platelet activation state is an indispensable part of thrombosis treatment. This review describes changes in the energy metabolism of platelets during thrombosis and their potential molecular mechanisms. The metabolic flexibility of energy substrate selection in activated platelets is discussed briefly, along with strategies by which platelet activation and thrombosis formation can be blocked by targeting activated platelet metabolism.

Keywords

thrombosis

platelets

glycolysis

fatty acid metabolism

amino acid metabolism

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